Principal Scientist - Antibody Discovery and Protein Engineering
Company: SystImmune, Inc.
Location: Redmond
Posted on: January 11, 2021
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Job Description:
Located in Redmond WA, SystImmune Inc. is a bio-pharmaceutical
company focused on the treatment of cancer through developing novel
therapeutic multi-specific antibodies, as well as antibody-drug
conjugates (ADC's). Our objective is to create biologics that work
through systematic intervention on the solid tumor
micro-environment, to either directly attack the tumor and/or to
activate the immune system to attack the tumor. We are seeking a
talented Principal Scientist with extensive experience in
antibody-based therapeutics, in Antibody Discovery and Protein
Engineering Department. The successful candidate will have a
tracked record of antibody discovery humanization, engineering,
molecular biology, purification and characterization. Essential
Duties and Responsibilities: Oversee antibody discovery,
humanization, engineering and characterization for novel
therapeutic multi-specific antibodies and Antibody Drug Conjugate
(ADC). Lead and establish protein Structure --- Function ---
Stability platform In-depth experience in protein modeling and
computational design Responsible for candidate optimization,
selection, and validation. Hands on in homology modeling, mammalian
expression, surface plasmon resonance, flow cytometry, SDS-PAGE are
required Proficiency with Pymol, IgBlast, Discovery Studio, abYsis,
Geneious are required Proven experience in mentorship and team
management Prepare and review Standard Operating Procedures (SOP)
Support and closely work with other divisions to advance company
goals Work with R&D and manufacturing department in China. Plan
time to accommodate meetings and technical support with team
members in China Participate in timeline planning and decision
making regarding research priorities of company or department and
provide information on feasibility of prospective projects. Other
duties as assigned. Qualifications: To perform this job
successfully an individual must be able to perform each essential
duty satisfactorily. The requirements listed below are
representative of the knowledge, skill, and/or ability required.
Reasonable accommodations may be made to enable individuals with
disabilities to perform the essential functions. Education &
Experience PhD in Molecular Biology, Structural Biology,
Biochemistry or a related field with 8 years (PhD) of relevant
academic and/or pharmaceutical or biotech experience Strong
fundamental knowledge and experience in antibody discovery,
humanization and engineering Extensive experience with homology
modeling and structure-base design SystImmune offers a flexible
schedule, competitive salary, and generous benefits package,
including a health/dental/vision care package, employer retirement
match, and paid time off --- SystImmune is an Equal Opportunity
Employer. Interested applicants should send their CV and cover
letter.
Keywords: SystImmune, Inc., Redmond , Principal Scientist - Antibody Discovery and Protein Engineering, Engineering , Redmond, Washington
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