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Director, Antibody Discovery & Protein Engineering

Company: SystImmune
Location: Redmond
Posted on: August 6, 2022

Job Description:

Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADCs). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor. Summary: The Director, Antibody Discovery & Protein Engineering will be responsible for leading a group of scientists to design, immunize, engineer and characterized antibody drug candidates - in the format of ADC, bispecific and multi-specific antibodies. Essential Duties and Responsibilities:

  • Lead the antibody discovery and protein engineering technologies,
  • Oversee the integration of new antibody drug development technologies with novel antibody formats
  • Responsible for antibody discovery immunization strategy and candidate validation
  • Lead antibody humanization and engineering for novel therapeutic multi-specific antibodies and Antibody Drug Conjugates (ADCs).
  • Use structural and sequence analysis to guide the design of drug candidates
  • Oversee drug candidate optimization, selection, validation, and stability study
  • Contributions to regulatory filings of biotherapeutics
  • Review and authorize Standard Operating Procedures (SOP)
  • Prepare reports and papers of completed projects for publication in technical journals, patents, presentation to regulatory agencies or at conferences, or use in further research activities.
  • Support and closely work with other departments
  • Work with R&D center in China. Plan time to accommodate meetings and technical support with team members in China
  • Support scientific discussions, high-level strategic scientific advice, inputs, and expertise to management, the Board, advisory groups, and scientific committees.
  • Participate in timeline planning and decision-making regarding research priorities of company or department and provide information on feasibility of prospective projects.
  • Other duties as assigned. Qualifications:To perform this job successfully an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform essential functions.

Keywords: SystImmune, Redmond , Director, Antibody Discovery & Protein Engineering, Executive , Redmond, Washington

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