Sr. Associate Scientist/Scientist/Sr. Scientist - Mass Spectrometry
Posted on: May 11, 2022
Located in Redmond WA, Systimmune Inc. is a bio-pharmaceutical
company focused on the treatment of cancer through developing novel
therapeutic multi-specific antibodies, as well as antibody-drug
conjugates (ADCs). Our objective is to create biologics that work
through systematic intervention on the solid tumor
micro-environment, to either directly attack the tumor and/or to
activate the immune system to attack the tumor.
SystImmune is seeking an experienced and energetic person with
hands-on LC/MS experience and proven abilities in characterizing
antibodies and multi-specifics proteins. The Sr Associate
Scientist/Scientist will be a part of a multidisciplinary team with
capabilities in molecular engineering, cell line development and
purification of large molecule therapeutics and is expected to
design, evaluate, and complete analytical development projects
consistent with company goals. This individual will be responsible
for timely planning and coordination of regulatory submissions and
will work closely with research and development associates to
provide detailed characterization to enable robust protein
production and formulation development.
Participate in the development, optimization, and validation of
bioanalytical methods for large molecule therapeutics and GMP
comparability studies using LC-MS assays.
Follow established protocols for sample management, sample
preparation, sample analysis, and data processing.
Provide high level analysis of experimental results, shows a deep
understanding of developing assays methods, troubleshooting, and
Prepare SOPs and IND documents as needed.
Responsible for day to day instrument operation, routine instrument
maintenance and troubleshooting.
Work on multiple projects within timelines according to high
scientific and ethical standards. Able to respond quickly to
Document, analyze, interpret, and present reports and results at
various meetings, both internally and externally.
Manage analytical transfer activities between Process development
and QC lab.
Plan time to accommodate meetings and technical support with team
members in China during operating hours in China.
Expertise in characterization of candidate biological drugs by
peptide mapping, post-translational modification assignment, glycan
characterization, disulfide mapping, intact and subunit mass
analysis, focusing on antibodies and fusion proteins.
Knowledge of sample preparation, and the fundamentals of
chromatography and mass spectrometry are needed as the candidate is
expected to identify assay issues and perform the associated
Maintain accurate records and write SOP, analytical and IND reports
for FDA submission
Hands on experience in operation, maintenance & trouble shooting of
Waters QTOF LC-MS instrument and associated software.
Provide technical/scientific guidance and training to team members
and research associates
The candidate must be able to prioritize his/her own work with
minimum direction from supervisor.
Excellent technical and problem-solving skills and ability to
perform detailed laboratory experiments.
Ability to work collaboratively with multiple groups on technical
projects exhibiting self-initiative and drive for results.
Proven record of being a fast learner, flexible, excellent
communicator and mindful team member.
Strong technical competency, well organized, good record keeping,
excellent oral and written communication skills.
Industry laboratory experience and bioanalysis training is
Experience with H/UPLC methods (SEC, IEX, HILIC, RP), CE-SDS, cIEF,
is a plus
Experience with complex Glycoproteins and MS characterization
Understanding of FDA regulations for submitting INDs.
Knowledge/experience with regulatory requirements is desirable.
Generate and analyzes data produced from a wide variety of
analytical techniques and analytic instrumentation
Education & Experience:
Education Required: PhD + 0-2 years' experience in Chemistry,
Biochemistry or related field
Keywords: SystImmune, Redmond , Sr. Associate Scientist/Scientist/Sr. Scientist - Mass Spectrometry, Other , Redmond, Washington
Didn't find what you're looking for? Search again!